On a bright and sunny day, two little mice dressed in Native American attire, clutching bows and axes while still wearing diapers, make their way to Jerry's doorstep. They hand Jerry a letter from the Mouse Orphanage, requesting that he take the two little ones on a journey. Jerry agrees, but little does he know he's inviting endless trouble. One of them goes up to Spike to provoke him, and fortunately, Jerry steps in just in time to defuse the situation; the other aims his bow at a bird sleeping in a tree, and though Jerry tries to stop him, he ends up getting shot himself. Jerry sets off with the two little ones, and soon they set their sights on Tom, who is fast asleep—even attempting to scalp him! Tom, disturbed and furious, relentlessly chases after these three pesky mice. An Indian war erupts in an instant, turning the small yard into a Wild West battlefield...