Once peaceful Swallow Falls was devastated by Flint Lockwood's (voiced by Bill Hader) genius invention, the Food Replicator. After finally managing to destroy the machine, he plans to rebuild a better home with Sam (voiced by Anna Faris) and the others. At this moment, Flint's greatest idol—Chester V (voiced by Will Forte), the CEO of Live Corp—descends from the sky. Chester is a brilliant inventor, and his company gathers the world's top scientists. Chester invites Flint to join Live Corp, promising to relocate the islanders to California while his company takes charge of cleaning up the ruined island. Determined to become a visionary inventor, Flint throws himself into research and development. Meanwhile, troubling news arrives from his hometown. Many of the cleanup crew have been captured by living food, suggesting that the Food Replicator was not completely destroyed and has evolved in ways Flint never anticipated. 　　Under Chester's orders, Flint, Sam, his father, and their other companions embark on a journey back home to find a solution to the crisis...