First-year high school student Yagiri Ageha one day picks up a "red telephone card" left in a public phone booth. A few days later, his childhood friend and classmate, Amamiya Sakurako, who had the same telephone card, disappears. To search for her, Ageha accesses the "secret society PSYREN," rumored to be behind the nationwide series of mysterious "spirit away" disappearances. And so, a life-or-death game begins─