In the sequel to the original animated series, the iconic Valerie Frizzle (now Professor Frizzle) earns her Ph.D. and retires from teaching at Walkerville Elementary School. She hires her younger sister, Miss Fiona Frizzle, to take over the class and entrusts her with the keys to the Magic School Bus. The children embark on thrilling new field trips, exploring new locations, creatures, time periods, and more to uncover the wonders of science, educating viewers along the way aboard the eponymous Magic School Bus.