It is a continuation of the Jonny Quest (1964) series and The New Adventures of Jonny Quest (1986) series, following the young adventurers Jonny Quest, Hadji Singh, and Jessie Bannon as they accompany Dr. Benton Quest and bodyguard Race Bannon to investigate strange phenomena, legends, and mysterious events in exotic lands. The plot also unfolds in a virtual realm called QuestWorld, depicted through 3D computer animation to render this three-dimensional cyberspace domain.