Puppy Patch embarks on a grand adventure on the streets of London. After being accidentally left behind in the city and separated from his family, he unexpectedly gets the chance to meet his most admired TV dog star, Thunderbolt, and becomes his best partner. Meanwhile, the wicked Cruella once again sets her sights on his sibling puppies, as she has met an artist named Lars this time, hoping to inspire his creations with black-and-white spots. Thus, she commits another Dalmatian kidnapping. This time, puppy Patch must join forces with Thunderbolt to launch a rescue mission!